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Related Experiment Video

Updated: Jun 2, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
09:11

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Published on: April 9, 2019

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Optimising prostate biopsies and imaging for the future-a review.

Kimberley Chan1, Drkhairul Asri Mohammad Ghani2, Jeremy Teoh3

  • 1Department of Urology, Hertfordshire and Bedfordshire Urological Cancer Center, Lister Hospital, Stevenage.

Urologic Oncology
|September 19, 2024
PubMed
Summary

Transrectal ultrasound guided prostate biopsy (TRUS-Bx) misses significant cancer and risks sepsis. Transperineal prostate biopsy (TP-Bx) and advanced imaging like PSMA-PET offer improved prostate cancer diagnosis.

Keywords:
Magnetic resonance imaging (MRI)Positron emission tomography (PET)Prostate cancerProstate specific membrane antigen (PSMA)Transperineal prostate biopsy

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Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
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A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
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Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

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71

Area of Science:

  • Urology
  • Oncology
  • Radiology

Background:

  • Transrectal ultrasound guided prostate biopsy (TRUS-Bx) is a conventional method for prostate cancer diagnosis.
  • TRUS-Bx has limitations, including missing up to 18% of clinically significant prostate cancer (csPCa) and a sepsis risk of 2.4%.
  • Transperineal prostate biopsy (TP-Bx) has emerged as an alternative technique.

Purpose of the Study:

  • To review current prostate biopsy techniques.
  • To provide an update on advanced prostate imaging modalities.
  • To highlight the role of prostate-specific membrane antigen-positron emission tomography (PSMA-PET) in prostate cancer detection.

Main Methods:

  • Narrative review of existing literature on prostate biopsy and imaging.
  • Discussion of the evolution from TRUS-Bx to TP-Bx.
  • Focus on the diagnostic capabilities of multiparametric MRI (mpMRI) and PSMA-PET.

Main Results:

  • TRUS-Bx can miss clinically significant prostate cancer.
  • mpMRI aids in visualizing suspicious areas, potentially avoiding unnecessary biopsies.
  • PSMA-PET shows high promise for primary diagnosis and detecting metastatic lesions with greater accuracy than conventional imaging.

Conclusions:

  • TP-Bx offers an alternative to TRUS-Bx, addressing some of its limitations.
  • Advanced imaging, particularly PSMA-PET, is revolutionizing prostate cancer diagnostics.
  • These advancements aim to improve the accuracy and efficiency of prostate cancer detection and management.