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Neural stimulation and modulation with sub-cellular precision by optomechanical bio-dart
Guoshuai Zhu1, Jianyun Xiong1, Xing Li1
1Guangdong Provincial Key Laboratory of Nanophotonic Manipulation, Institute of Nanophotonics, College of Physics and Optoelectronic Engineering, Jinan University, Guangzhou, 511443, China.
Light, Science & Applications
|September 19, 2024
Summary
Researchers developed an optomechanical bio-dart from sunflower pollen for precise neural stimulation. This method allows subcellular control of neuronal activity and can be used for drug delivery and in vivo studies.
Area of Science:
- Neuroscience
- Biophysics
- Biotechnology
Background:
- High-resolution neural stimulation is vital for understanding neuronal function and disease.
- Current methods face challenges in achieving subcellular precision and biocompatibility.
Purpose of the Study:
- To develop a novel optomechanical method for precise neural stimulation and modulation at the subcellular level.
- To demonstrate the application of this technique for drug delivery and in vivo studies.
Main Methods:
- Utilized optically controlled bio-darts derived from sunflower pollen.
- Propelled bio-darts using optical scattering force via an optical fiber probe.
- Achieved submicrometer spatial resolution for neural stimulation via mechanosensitive ion channel activation.
Main Results:
- Demonstrated controllable modulation of single neurons, including subcellular structures like dendrites, axons, and soma.
- Showcased the bio-dart's capability as a drug delivery tool.
- Successfully performed in vivo neural stimulation in larval zebrafish.
Conclusions:
- The optomechanical bio-dart offers a novel approach for high-precision neural stimulation and modulation.
- This technique holds promise for advancing research in neuronal plasticity and neuromodulation.
