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Updated: May 2, 2026

Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells
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Lipophilic compounds restore function to neurodevelopmental-associated KCNQ3 mutations.

Michaela A Edmond1,2, Andy Hinojo-Perez1, Mekedlawit Efrem3

  • 1Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.

Communications Biology
|September 19, 2024
PubMed
Summary

Dysfunctional KCNQ3 potassium channels cause neurodevelopmental disorders. Polyunsaturated fatty acids (PUFAs) offer potential therapies by restoring KCNQ3 channel function, targeting specific mutation mechanisms.

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