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Intersample variation in bone histomorphometry: comparison between parameter values measured on two contiguous

P M Chavassieux, M E Arlot, P J Meunier

    Calcified Tissue International
    |July 1, 1985
    PubMed
    Summary
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    Intersample variations in bone histomorphometry differ by disease. These bone biopsy variations are significant for individual patients but less so for groups, impacting disease monitoring and therapy evaluation.

    Area of Science:

    • Bone biology
    • Metabolic bone diseases
    • Histomorphometry

    Background:

    • Bone histomorphometry is crucial for diagnosing and managing metabolic bone diseases.
    • Understanding intersample variation is essential for accurate patient assessment and treatment monitoring.

    Purpose of the Study:

    • To evaluate intersample variations in bone histomorphometric parameters across various metabolic bone diseases.
    • To determine the impact of these variations on individual patients versus groups.

    Main Methods:

    • Two contiguous transiliac bone biopsies were analyzed from 55 subjects with conditions including osteoporosis, renal osteodystrophy, and osteomalacia.
    • Key histomorphometric parameters (e.g., trabecular bone volume, osteoid surfaces, resorption surfaces, calcification rate) were measured.

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  • Intersample differences were quantified using percent mean difference and intrapair coefficient of variation.

    • Main Results:

    • Intersample variation for bone histomorphometric parameters significantly differs based on the specific metabolic bone disease.
    • Confidence intervals for individual subjects highlight substantial variations (e.g., 69% for trabecular resorption surfaces in primary hyperparathyroidism).
    • Variations are considerably lower when analyzing data from groups of 10 or 20 patients.

    Conclusions:

    • Bone histomorphometric intersample variations are diagnosis-dependent and must be considered in clinical practice.
    • These findings are critical for interpreting serial biopsies in individual patients and for evaluating therapeutic efficacy.
    • The study underscores the importance of accounting for biopsy variability in research and clinical settings for metabolic bone diseases.