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Updated: Jun 12, 2025
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Enteric Bacterial Invasion Of Intestinal Epithelial Cells In Vitro Is Dramatically Enhanced Using a Vertical Diffusion Chamber Model
Published on: October 22, 2013
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Enteric pathogens relationship with small bowel histologic features of environmental enteric dysfunction in a
Najeeha T Iqbal1, Sarah Lawrence2, Tahmeed Ahmed3
1Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
The American Journal of Clinical Nutrition
|September 20, 2024
Summary
Detecting enteropathogens like norovirus, Shigella, Campylobacter, and ETEC in asymptomatic children is linked to Environmental Enteric Dysfunction (EED) histology. This finding helps understand EED causes and progression.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Microbiome Research
Background:
- Environmental Enteric Dysfunction (EED) is an acquired gut disorder linked to childhood growth faltering.
- Its etiology remains unknown, with limited research on the upper small bowel's role.
- Enteropathogenic carriage is prevalent in regions affected by EED.
Purpose of the Study:
- To investigate if detecting fecal enteropathogens predicts subsequent EED histology.
- To establish a link between specific pathogens and EED-related histopathological changes.
Main Methods:
- Fecal samples were collected from 245 undernourished children (<2 years) across three cohort studies.
- Duodenal biopsies were analyzed using semiquantitative histologic grading.
- Enteropathogens were detected using TaqMan array cards (TAC) and Luminex platforms.
Main Results:
- Norovirus and Shigella detection associated with enterocyte injury.
- Campylobacter linked to increased intraepithelial lymphocytes.
- Campylobacter and enterotoxigenic E. coli associated with a summative EED histopathology index score.
Conclusions:
- Asymptomatic enteropathogen detection is associated with EED histopathology.
- These findings provide a foundation for future EED etiology and pathogenesis research.
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