The Chemopreventive Impact of Diet-Derived Phytochemicals on the Adipose Tissue and Breast Tumor Microenvironment Secretome
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View abstract on PubMed
Summary
This summary is machine-generated.Cancer cell extracellular vesicles promote cancer-associated adipocytes. Diet phytochemicals like EGCG may alter this crosstalk, impacting cancer progression and obesity-related cancer chemoprevention.
Area Of Science
- Oncology
- Cell Biology
- Metabolism
Background
- Cancer cell-derived extracellular vesicles induce adipose-derived mesenchymal stem cells (ADMSCs) to become cancer-associated adipocytes (CAAs).
- This crosstalk between adipose tissue and the tumor microenvironment (TME) influences tumor growth and metastasis.
- Dietary phytochemicals, such as epigallocatechin-3-gallate (EGCG), show potential in regulating exosome-mediated signaling.
Purpose Of The Study
- To explore how dietary phytochemicals can modify the secretome and crosstalk between adipose tissue and the TME.
- To focus on the implications for breast cancer.
- To discuss the potential role in chemoprevention of obesity-related cancers.
Main Methods
- Review and discussion of existing literature on extracellular vesicles, ADMSC transformation, phytochemicals, and TME interactions.
- Analysis of signaling pathways involved in metabolic and inflammatory crosstalk.
- Focus on breast cancer models and obesity-related cancer chemoprevention.
Main Results
- Dietary phytochemicals may alter the secretome signature of cancer cells and ADMSCs.
- Phytochemicals could modulate the crosstalk dynamics between adipose tissue and the TME.
- Selected phytochemicals show promise in influencing cancer-associated adipocyte phenotypes.
Conclusions
- Diet-derived phytochemicals offer a potential strategy to disrupt cancer-promoting crosstalk between adipose tissue and the TME.
- EGCG and other polyphenols may play a role in the chemoprevention of obesity-related cancers.
- Targeting this crosstalk could lead to novel therapeutic and preventative approaches in oncology.
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