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Elevated high-sensitivity C-reactive protein (hs-CRP) is linked to cardiovascular risk. This study found hs-CRP correlates positively with triglycerides, folate, serum copper, and manganese, suggesting key inflammatory and micronutrient associations.

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Area of Science:

  • Clinical Chemistry
  • Cardiovascular Disease Research
  • Nutritional Science

Background:

  • Elevated high-sensitivity C-reactive protein (hs-CRP) indicates systemic inflammation and cardiovascular disease risk.
  • Abnormal lipid profiles and micronutrient deficiencies may contribute to increased hs-CRP levels.
  • Understanding serological cross-correlations is crucial for assessing cardiovascular health.

Purpose of the Study:

  • To investigate the associations between inflammatory markers, lipid profiles, and micronutrient levels.
  • To identify key serological correlations related to high-sensitivity C-reactive protein (hs-CRP).
  • To explore potential contributing factors to elevated hs-CRP.

Main Methods:

  • Retrospective analysis of 1,014 individuals.
  • Assessment of cardiovascular and micronutrient panels alongside hs-CRP.
  • Utilized parametric t-tests and Pearson's correlation for statistical analysis.

Main Results:

  • Significant sex-based variations observed for cholesterol, HDL, triglycerides, vitamin A, vitamin D3, serum copper, and valine.
  • Pearson's correlation revealed a significant positive association between hs-CRP and triglycerides.
  • A significant positive correlation was also found between hs-CRP and folate, serum copper, and manganese.

Conclusions:

  • Triglycerides, folate, serum copper, and manganese are significantly positively correlated with hs-CRP.
  • These findings highlight specific micronutrient and lipid markers associated with systemic inflammation.
  • Further research can explore targeted interventions based on these identified associations.