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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Cd10 Immunohistochemical Expression In Breast Carcinoma And Its Correlation With Clinicopathological Parameters

CD10 Immunohistochemical Expression in Breast Carcinoma and Its Correlation With Clinicopathological Parameters

Vijayalaxmi S Patil1, Shraddha Barate2

  • 1Pathology, Shri B. M. Patil Medical College, Hospital and Research Centre, Bijapur Lingayat District Education (Deemed to Be University), Vijayapura, IND.

Cureus
|September 20, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Stromal CD10 expression in breast cancer is linked to more aggressive tumor features. This finding suggests stromal CD10 may serve as an independent prognostic marker for invasive breast carcinoma.

Area of Science:

  • Oncology
  • Pathology
  • Immunohistochemistry

Background:

  • Stromal-tumor cell interactions are critical in breast cancer progression and treatment response.
  • Stromal CD10 expression is associated with aggressiveness in various epithelial cancers.
  • Stromal markers for invasive breast cancer prognosis are under-researched.

Purpose of the Study:

  • To investigate the immunohistochemical expression of CD10 in breast carcinoma stromal cells.
  • To correlate stromal CD10 expression with prognostic factors including tumor size, grade, lymph node status, and ER, PR, and HER2-neu status.

Main Methods:

  • A cross-sectional study of 50 invasive breast carcinoma mastectomy specimens.
  • Exclusion of patients who received neoadjuvant therapy or chemotherapy.
  • Immunohistochemical staining for CD10 and correlation with clinicopathological factors.
Keywords:
breast cancerer/primmunohistochemistryprognosis

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Main Results:

  • Stromal CD10 expression was observed in 80% of cases.
  • A significant association was found between stromal CD10 expression and higher histological grade (p < 0.0001).
  • Stromal CD10 expression was significantly associated with Estrogen Receptor (ER)-negative (p < 0.045) and Progesterone Receptor (PR)-negative (p < 0.048) status.

Conclusions:

  • Stromal CD10 expression is strongly associated with negative prognostic markers like higher tumor grade and ER/PR-negative status.
  • Stromal CD10 expression shows potential as an independent prognostic marker in breast carcinoma.
  • Further research into stromal CD10 could refine breast cancer prognostication and treatment strategies.
stromal cd10
tumor grade