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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.7K

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Related Experiment Video

Updated: Jun 12, 2025

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Decrypting Skin Microbiome in Psoriasis: Current Status.

Preeti Arya1,2, Manpreet Kaur1,3, Stanzin Chosyang1,3

  • 1Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.

Journal of Psoriasis and Psoriatic Arthritis
|September 20, 2024
PubMed
Summary
This summary is machine-generated.

Psoriasis involves skin microbiome imbalances. Key bacterial genera in lesional psoriatic skin (LPS) can serve as a microbial signature for new psoriasis therapies.

Keywords:
human skin microbiomeinflammationpsoriasispsoriasis etiologyskin

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Area of Science:

  • Dermatology
  • Microbiology
  • Immunology

Background:

  • Psoriasis is a chronic, inflammatory autoimmune skin disease with complex causes.
  • Research indicates that imbalances in the skin microbiome (dysbiosis) are linked to psoriasis development and inflammation.

Purpose of the Study:

  • To review psoriasis skin microbiome studies from the past 20 years.
  • To identify key bacterial genera that could act as a microbial signature for therapeutic interventions in psoriasis.

Main Methods:

  • Systematic literature search and full-text analysis of relevant studies.
  • Adherence to PRISMA guidelines for systematic reviews.

Main Results:

  • Specific bacterial genera show different abundance in lesional psoriatic skin (LPS) compared to normal skin (NS).
  • These genera may form a microbial signature for psoriasis and help understand skin homeostasis.
  • Multiple bacterial species, not just one, are crucial for psoriasis etiology.
  • Reduced microbiome stability and increased diversity may worsen psoriatic lesions.

Conclusions:

  • Skin microbiome dysbiosis is significant in psoriasis.
  • Future research should focus on developing novel therapies using microbial genomic and metabolomic data.