Association between immune-related adverse events and the prognosis of patients with gastric cancer treated with nivolumab: a meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Immune-related adverse events (irAEs) are linked to improved survival outcomes for advanced gastric cancer (GC) patients treated with nivolumab. Experiencing irAEs significantly boosts overall survival and progression-free survival rates.
Area Of Science
- Oncology
- Immunotherapy
- Clinical Research
Background
- Nivolumab is a key treatment for advanced gastric cancer (GC).
- Immune-related adverse events (irAEs) are common side effects of nivolumab.
- The prognostic significance of irAEs in GC patients treated with nivolumab requires investigation.
Purpose Of The Study
- To systematically review and analyze the relationship between irAEs and patient prognosis in advanced GC treated with nivolumab.
- To evaluate the impact of irAEs on survival outcomes and response rates.
Main Methods
- A systematic literature search was conducted across four major databases (Cochrane, PubMed, Embase, Web of Science) up to March 27, 2024.
- Studies were included if they reported on nivolumab treatment for GC and assessed irAEs.
- Key outcome measures included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR).
Main Results
- Six studies comprising 393 patients met the inclusion criteria.
- Patients who developed irAEs showed significantly superior OS (pooled HR=0.4) and PFS (pooled HR=0.5) compared to those without irAEs.
- irAEs were associated with higher ORR (24.7% vs 6.4%) and DCR (86.0% vs 30.3%).
Conclusions
- The occurrence of irAEs in advanced GC patients treated with nivolumab is significantly correlated with improved survival benefits.
- irAEs may serve as a predictive biomarker for better treatment response and prognosis.
- Further research should explore the mechanisms underlying this association.
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