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Zinc: a potential star for regulating peritoneal fibrosis
Jian Li1, Xinyang Li1, Yangwei Wang1
1Department of Nephrology, The Second Hospital of Jilin University, Changchun, China.
Frontiers in Pharmacology
|September 20, 2024
Summary
Zinc may protect the peritoneum from fibrosis during dialysis. This study reviews how zinc, an antioxidant, might prevent peritoneal fibrosis in end-stage renal disease patients undergoing peritoneal dialysis.
Area of Science:
- Nephrology
- Biochemistry
- Pathology
Background:
- Peritoneal dialysis (PD) is a renal replacement therapy for end-stage renal disease (ESRD).
- PD solutions can cause peritoneal membrane (PM) damage, leading to fibrosis and ultrafiltration failure.
- Oxidative stress (OS) is implicated in the progression of peritoneal fibrosis.
Purpose of the Study:
- To analyze the potential mechanisms by which zinc supplementation may prevent peritoneal fibrosis.
- To review current research on the role of zinc as an antioxidant in PD-related complications.
Main Methods:
- Literature review of domestic and international studies.
- Analysis of research on zinc's antioxidant properties and its effect on peritoneal fibrosis.
- Synthesis of evidence regarding zinc's role in preventing PM damage during PD.
Main Results:
- Zinc deficiency is common in PD patients.
- Zinc acts as an antioxidant, potentially mitigating OS-induced PM damage.
- Evidence suggests zinc may slow the progression of peritoneal fibrosis.
Conclusions:
- Zinc's antioxidant properties may offer a protective effect against peritoneal fibrosis in ESRD patients on PD.
- Further research is warranted to confirm zinc's therapeutic potential in preventing PD-related complications.
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