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Zinc: a potential star for regulating peritoneal fibrosis

Jian Li1, Xinyang Li1, Yangwei Wang1

  • 1Department of Nephrology, The Second Hospital of Jilin University, Changchun, China.

Frontiers in Pharmacology
|September 20, 2024
PubMed

Insights

Zinc may protect the peritoneum from fibrosis during dialysis. This study reviews how zinc, an antioxidant, might prevent peritoneal fibrosis in end-stage renal disease patients undergoing peritoneal dialysis.

Area of Science:

  • Nephrology
  • Biochemistry
  • Pathology

Background:

  • Peritoneal dialysis (PD) is a renal replacement therapy for end-stage renal disease (ESRD).
  • PD solutions can cause peritoneal membrane (PM) damage, leading to fibrosis and ultrafiltration failure.
  • Oxidative stress (OS) is implicated in the progression of peritoneal fibrosis.

Purpose of the Study:

  • To analyze the potential mechanisms by which zinc supplementation may prevent peritoneal fibrosis.
  • To review current research on the role of zinc as an antioxidant in PD-related complications.

Main Methods:

  • Literature review of domestic and international studies.
  • Analysis of research on zinc's antioxidant properties and its effect on peritoneal fibrosis.
  • Synthesis of evidence regarding zinc's role in preventing PM damage during PD.

Main Results:

  • Zinc deficiency is common in PD patients.
  • Zinc acts as an antioxidant, potentially mitigating OS-induced PM damage.
  • Evidence suggests zinc may slow the progression of peritoneal fibrosis.

Conclusions:

  • Zinc's antioxidant properties may offer a protective effect against peritoneal fibrosis in ESRD patients on PD.
  • Further research is warranted to confirm zinc's therapeutic potential in preventing PD-related complications.
Keywords:
end-stage renal diseaseoxidative stressperitoneal dialysisperitoneal fibrosiszinc

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