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Updated: Jul 31, 2026

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Lipid metabolic rewiring in glioma‑associated microglia/macrophages (Review)

Yixuan Ma1, Yimin Huang1, Feng Hu2

  • 1Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

International Journal of Molecular Medicine
|September 20, 2024
PubMed

Insights

This review explores how lipid metabolism in glioma-associated microglia/macrophages (GAMs) impacts brain tumor growth. Understanding these metabolic changes offers new therapeutic targets for glioma treatment.

Area of Science:

  • Neuro-oncology
  • Immunology
  • Metabolic research

Background:

  • Gliomas are common brain tumors in children and adults.
  • Microglia are key immune cells in the central nervous system (CNS).
  • Glioma-associated microglia/macrophages (GAMs) exhibit dynamic metabolic and phenotypic changes during tumor progression.

Purpose of the Study:

  • To review the role of lipid metabolism in GAMs within the glioma context.
  • To highlight the significance of macrophage metabolic reprogramming in tumor growth.
  • To identify potential therapeutic targets based on lipid metabolism in GAMs.

Main Methods:

  • Literature review focusing on lipid metabolism in microglia and macrophages.
  • Analysis of metabolic reprogramming in GAMs.
  • Identification of therapeutic strategies targeting lipid metabolism.

Main Results:

  • GAMs significantly alter their lipid metabolic profiles in response to glioma signals.
  • Macrophage metabolic reprogramming is increasingly recognized for its role in tumor growth.
  • Current data on lipid metabolism in GAMs is limited, necessitating further investigation.

Conclusions:

  • Lipid metabolism plays a crucial role in the function of GAMs and glioma progression.
  • Targeting lipid metabolism in GAMs presents a promising therapeutic avenue for glioma.
  • This review serves as a foundational resource for future research on GAMs and lipid metabolism.
Keywords:
cancergliomalipid metabolismmacrophagesmicroglia

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