JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

State-of-the-art in high throughput organ-on-chip for biotechnology and pharmaceuticals

  • 0Ginkgo Bioworks Inc., Boston, MA, USA.
Clinical and Experimental Reproductive Medicine +

|

September 20, 2024

|

September 20, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

High-throughput organ-on-chip (OoC) systems offer a powerful alternative for drug discovery, enhancing predictivity and reducing research costs. This study reviews commercial HT-OoC products and discusses industrialization trends.

Area Of Science

  • Biotechnology
  • Pharmacology
  • Drug Discovery

Background

  • The pharmaceutical industry faces increasing demand for efficient compound screening.
  • Traditional drug discovery models have limitations in predictivity and physiological relevance.
  • High-throughput screening (HTS) integrates automation, robotics, and AI for accelerated experimentation.

Purpose Of The Study

  • To provide an overview of commercial high-throughput organ-on-chip (HT-OoC) systems.
  • To discuss recent research and development trends in the industrialization of HT-OoC technology.
  • To highlight the potential of HT-OoC systems as a disruptive technology in pharmaceutical R&D.

Main Methods

  • Review of commercially available HT-OoC products.
  • Analysis of current R&D trends towards industrializing HT-OoC platforms.
  • Discussion of the integration of OoC systems into modern drug discovery workflows.

Main Results

  • Several commercial HT-OoC systems are available, offering enhanced physiological relevance.
  • Significant R&D efforts are focused on scaling and standardizing HT-OoC technology for industrial use.
  • HT-OoC systems show promise in improving the predictivity of drug efficacy and toxicity.

Conclusions

  • High-throughput organ-on-chip systems represent a significant advancement over traditional in vitro and animal models.
  • The industrialization of HT-OoC technology is crucial for its widespread adoption in drug discovery and development.
  • These advanced platforms have the potential to revolutionize pharmaceutical R&D by increasing efficiency and reducing costs.

Keywords: