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Epithelial Interleukin-1 Receptor-Like-1 Activation Is Contingent on Interleukin-33 Isoforms and Asthma-Related

Michael A Portelli1, Maria E Ketelaar2,3, Stewart Bates4

  • 1Centre for Respiratory Research, National Institute for Health Research Nottingham Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|September 20, 2024
PubMed
Summary

Genetic variants in the interleukin-33 receptor (IL1RL1) influence asthma risk. Specific IL-33 isoforms, particularly cleaved forms, activate IL1RL1 signaling, suggesting targeted therapies for asthma patients with risk haplotypes.

Keywords:
IL1RL1IL33signallingvariation

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