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Progress in diagnosis and treatment of hypertension combined with left ventricular hypertrophy

Yongjin Han1, Yanqiu Li2, Zhen Wu2

  • 1Department of Cardiology, First Hospital of China Medical University, Shenyang, Liaoning Province, China.

Annals of Medicine
|September 20, 2024
PubMed

Insights

This review synthesizes research on hypertension and left ventricular hypertrophy, highlighting recent progress in diagnosis, pathophysiology, and treatment, including promising new drug trials for this cardiovascular condition.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Research
  • Public Health

Background:

  • Hypertension is a global cardiovascular problem causing significant left ventricular damage.
  • Left ventricular hypertrophy (LVH) increases cardiovascular disease risk and mortality.
  • LVH is a critical indicator of hypertension's impact on heart health.

Purpose of the Study:

  • To systematically review the literature on the prevalence and associations of hypertension and LVH.
  • To explore the progression and clinical outcomes related to hypertension-induced LVH.
  • To identify current research trends and therapeutic advancements.

Main Methods:

  • A scoping review methodology was employed, following Arksey & O'Malley's framework.
  • A comprehensive search of the PubMed database was conducted without language restrictions.
  • Data were extracted from 110 selected articles published between 1987 and 2024.

Main Results:

  • The review included 110 studies, with a significant portion (55.5%) published in the last five years.
  • Research spanned diagnosis, epidemiology, pathophysiology, prognosis, and treatment of hypertension with LVH.
  • A notable increase in studies from 2024 (14.5%) indicates current research activity.

Conclusions:

  • The literature reveals diverse clinical progress in managing hypertension and LVH.
  • Recent clinical trials of novel drugs offer significant hope for improved treatment outcomes.
  • Continued research is vital for understanding and combating the effects of hypertension on the left ventricle.
Abstract

Keywords:
Left ventricular hypertrophydiagnostic evaluationhypertension

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