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Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

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Exploring amyotrophic lateral sclerosis through the visual system: A systematic review.

Raoul K Khanna^1,2, Sophie Catanese^1,2, Geoffroy Mortemousque¹

¹Department of Ophthalmology, Bretonneau University Hospital of Tours, Tours, France.

European Journal of Neurology

|September 20, 2024

Summary

Investigating the visual system in people with amyotrophic lateral sclerosis (ALS) reveals impairments even without symptoms. This highlights ALS as a multisystem disease and suggests vision tests could be key biomarkers.

Keywords:

amyotrophic lateral sclerosis motor neuron disease oculomotor ophthalmology retina vision

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Area of Science:

Neuroscience
Ophthalmology
Neurology

Background:

The human visual system is extensively studied for eye structures and movements.
Over 20 years, afferent and efferent visual system components in people with ALS (pwALS) have been investigated.
Visual system exploration may offer innovative biomarkers for ALS phenotypic variability.

Conclusions:

Investigating the oculomotor system and ocular surface shows promise for identifying new diagnostic biomarkers in pwALS.
Longitudinal studies are necessary to find indicators of disease progression and treatment response.