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Related Experiment Video

Updated: Jun 12, 2025

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Vitamin D in the critically ill - update 2024.

Christina Geiger1, James Dayre McNally2, Kenneth B Christopher3

  • 1Division of Infectious Diseases, Medical University of Graz, Graz, Austria.

Current Opinion in Clinical Nutrition and Metabolic Care
|September 20, 2024
PubMed
Summary
This summary is machine-generated.

Vitamin D deficiency is common in critically ill patients and linked to worse outcomes. Supplementation is safe and may offer benefits, though more research is needed to confirm efficacy.

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Area of Science:

  • Critical Care Medicine
  • Endocrinology
  • Nutritional Science

Background:

  • Vitamin D deficiency is prevalent in critically ill patients, affecting both children and adults.
  • This deficiency is associated with increased mortality, morbidity, sepsis, and organ failure.

Purpose of the Study:

  • To review recent literature on vitamin D in critically ill patients.
  • To assess the potential benefits and safety of vitamin D supplementation in the ICU.

Main Methods:

  • Review of the latest publications on vitamin D in critically ill populations.
  • Analysis of randomized controlled trials (RCTs) concerning vitamin D in intensive care units (ICUs).

Main Results:

  • Vitamin D deficiency is linked to higher mortality and morbidity, including sepsis and acute organ failure.
  • Acute vitamin D treatment is a potential ICU intervention due to its low cost and safety.
  • Existing RCTs have limitations, including heterogeneity in patient populations, dosing, and outcomes.

Conclusions:

  • Vitamin D supplementation is a safe and simple intervention for critically ill patients.
  • Normalizing vitamin D levels may improve outcomes across various ICU diagnoses.
  • Standard daily doses of vitamin D3 are recommended for critically ill patients pending further research.