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Global Processing Deficit in Amnestic Mild Cognitive Impairment.

Laura Veronelli1,2, Roberta Daini1, Alice Mannino2

  • 1Department of Psychology, University of Milano-Bicocca, Milan, Italy.

Journal of Alzheimer'S Disease : JAD
|September 20, 2024
PubMed
Summary
This summary is machine-generated.

Early Alzheimer's disease, known as amnestic mild cognitive impairment (MCI), may show deficits in global processing. Investigating these visuo-perceptual and attentional issues could aid early diagnosis.

Keywords:
Alzheimer’s diseaseNavonfocal attentionglobal processing deficitsmild cognitive impairmentsimultanagnosiavisuo-perceptual processing

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Ophthalmology

Background:

  • Visuo-perceptual and visuo-attentional disorders are not routinely assessed in early Alzheimer's disease, specifically amnestic mild cognitive impairment (MCI).
  • Conditions like global processing deficit and simultanagnosia are under-investigated in prodromal Alzheimer's disease.

Purpose of the Study:

  • To evaluate global processing abilities in individuals with amnestic MCI using Navon's paradigm.
  • To investigate visuo-perceptual and attentional components related to simultanagnosia in amnestic MCI.

Main Methods:

  • Sixteen patients with amnestic MCI (single-domain and multiple-domain) and 16 matched controls participated.
  • Participants identified global and local elements of hierarchical Navon letters and named solid letters.

Main Results:

  • Multiple-domain amnestic MCI patients showed reduced accuracy in global hierarchical stimulus processing compared to controls.
  • Single-case analyses indicated potential global processing impairment in single-domain amnestic MCI.
  • Impaired performance on the Navon task correlated with deficits in perceptual and/or visual focal attention.

Conclusions:

  • Early holistic processing dysfunction is detectable in amnestic MCI.
  • Visuo-perceptual and visual focal attention deficits, seen in Posterior Cortical Atrophy and simultanagnosia, may occur in amnestic MCI.
  • Identifying global processing deficits in MCI can support early diagnosis and disease monitoring.