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Updated: May 5, 2026
Electrolytic Inferior Vena Cava Model EIM of Venous Thrombosis
Published on: July 12, 2011
Association between PAI-1 4G/5G genotype and residual thrombus in acute mesenteric venous thrombosis
Bin Liu1, Hai Feng1, Wenrui Li2
1Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Objective:
Plasminogen activator inhibitor-1 (PAI-1) is the most important inhibitor of plasminogen activator. The functional 4G/5G polymorphism of the gene coding for PAI-1 may affect PAI-1 plasmatic activity, influencing the imbalance between coagulation and fibrinolysis cascades. In this study, we investigated the association between the PAI-1 4G/5G genotype and the development and residual thrombus of acute primary mesenteric venous thrombosis (MVT).
Methods:
The clinical data of 34 patients who underwent acute primary MVT were retrospectively reviewed. Fluorescence in situ hybridization was used to determine if patients had the 4G/5G polymorphism in the promoter of the PAI-1 gene. Patients were stratified according to the genotype of PAI-1.
Results:
11 patients (32.3%) were homozygous for the 4G genotype, 23 patients (67.6%) were non-homozygous for the 4G genotype (5G/5G). The extent of thrombosis was not correlated with the PAI-4G/5G polymorphism. After a mean follow-up of 16.6 ± 10.4 months, the 4G/4G genotype had a significantly larger thrombus burden (p < 0.05). 54% of patients in the 4G/4G genotype group had no lessening in the degree of mesenteric venous thrombosis, significantly higher than other patients (4G/5G + 5G/5G genotypes) (p < 0.05).
Conclusion:
The PAI-1 4G/4G predicts residual thrombus of mesenteric veins after the acute phase.
Insights
The Plasminogen activator inhibitor-1 (PAI-1) 4G/4G genotype is linked to greater residual thrombus in mesenteric venous thrombosis (MVT) patients. This PAI-1 4G/4G genotype predicts persistent thrombus after the acute phase of MVT.
Area of Science:
- Genetics and Thrombosis
- Vascular Medicine
Background:
- Plasminogen activator inhibitor-1 (PAI-1) regulates fibrinolysis.
- The PAI-1 4G/5G gene polymorphism may influence PAI-1 activity and coagulation-fibrinolysis balance.
Purpose of the Study:
- To investigate the association between PAI-1 4G/5G genotype and the development and residual thrombus in acute primary mesenteric venous thrombosis (MVT).
Main Methods:
- Retrospective review of 34 acute primary MVT patients.
- Fluorescence in situ hybridization to determine PAI-1 4G/5G polymorphism.
- Stratification of patients based on PAI-1 genotype.
Main Results:
- The 4G/4G genotype was observed in 32.3% of patients, and non-4G genotypes (4G/5G, 5G/5G) in 67.6%.
- No correlation was found between PAI-1 genotype and the initial extent of thrombosis.
- Patients with the 4G/4G genotype showed a significantly larger thrombus burden and less thrombus resolution at follow-up (p < 0.05).
Conclusions:
- The PAI-1 4G/4G genotype is a predictor of residual thrombus in mesenteric veins following the acute phase of MVT.
