Genetic variants and social benefit receipt in premenopausal women with breast cancer treated with docetaxel: a Danish population-based cohort study

Julie A Schmidt ¹, Cathrine F Hjorth ², Dóra K Farkas ²

¹Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Olof Palmes Allé 43-45, 8200, Aarhus N, Denmark. js@clin.au.dk.
²Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Olof Palmes Allé 43-45, 8200, Aarhus N, Denmark.
³Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark.
⁴Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
⁵Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark.
⁶Department of Clinical Medicine and Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.
⁷Danish Breast Cancer Group, Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
⁸Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
⁹Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
¹⁰Department of Surgery, The Robert Larner, M.D. College of Medicine, The University of Vermont, Burlington, VT, USA.

⁰Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Olof Palmes Allé 43-45, 8200, Aarhus N, Denmark. js@clin.au.dk.

Breast Cancer Research and Treatment +

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September 20, 2024

View abstract on PubMed

Summary

This study found no significant link between specific genetic variations (SNPs) and the need for social benefits in breast cancer survivors after taxane chemotherapy. The selected genetic markers did not clinically impact benefit receipt in this patient group.

Area Of Science

Oncology
Pharmacogenomics
Social Sciences

Background

Taxane-based chemotherapy for breast cancer can lead to long-lasting side effects, potentially increasing patients' need for social benefits.
Single nucleotide polymorphisms (SNPs) may influence chemotherapy side effects and subsequent social benefit utilization.

Purpose Of The Study

To investigate the association between specific SNPs (related to taxane metabolism, transport, toxicity, or DNA repair) and the receipt of social benefits in breast cancer patients.
To determine if genetic variations impact the need for health-related or labor market-related benefits post-chemotherapy.

Main Methods

Study included 2430 premenopausal women with stage I-III breast cancer treated with docetaxel-based chemotherapy.
Genotyped 21 SNPs from tumor samples and analyzed nationwide registry data on social benefit payments from 1 year pre-diagnosis to 5 years post-diagnosis.
Used negative binomial regression to calculate rate ratios (RRs) comparing benefit receipt in variant carriers versus non-carriers.

Main Results

Approximately 12% of women received health-related benefits pre-diagnosis, 80% at diagnosis, and ~24% 2-5 years post-diagnosis.
Labor market-related benefits were received by 3-6% of patients.
All calculated rate ratios (RRs) for the association between SNPs and social benefit receipt were near-null and imprecise.

Conclusions

The investigated single nucleotide polymorphisms (SNPs) showed no clinically significant impact on social benefit receipt among premenopausal breast cancer survivors undergoing docetaxel treatment.
These genetic markers do not appear to be reliable predictors of social benefit needs in this population.

Keywords:

Breast cancer Single-nucleotide polymorphisms Social benefits Survivorship Taxane

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