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Physalaemin inhibits thyrotropin secretion in rats.

T Mitsuma, T Nogimori, M Chaya

Experimental and Clinical Endocrinology

|June 1, 1985

Summary

Physalaemin significantly inhibits thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) secretion in rats by acting on the hypothalamus. Its effects on TSH release are modulated by central nervous system amines.

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Area of Science:

Neuroendocrinology
Pharmacology

Background:

Thyrotropin-releasing hormone (TRH) regulates the secretion of thyrotropin (TSH).
Physalaemin is a peptide with potential neuroendocrine effects.

Purpose of the Study:

To investigate the effects of physalaemin on TRH and TSH secretion in rats.
To elucidate the mechanism of physalaemin's action on the hypothalamic-pituitary-thyroid axis.

Main Methods:

Intravenous injection of physalaemin in rats.
Measurement of hypothalamic and plasma TRH, plasma TSH, and plasma thyroid hormone levels using radioimmunoassay.
Assessment of physalaemin's effects on cold- and TRH-stimulated TSH release.
Evaluation of the role of central nervous system amines using pharmacological pretreatments.

Main Results:

Physalaemin increased hypothalamic TRH content but decreased plasma TSH levels in a dose-dependent manner.
Physalaemin inhibited TRH and TSH responses to cold but not the TSH response to TRH.
Pretreatment with pimozide or para-chlorophenylalanine blocked physalaemin's inhibitory effect on TSH, suggesting amine involvement.

Conclusions:

Physalaemin inhibits TRH release from the hypothalamus.
The effects of physalaemin on TSH secretion are modulated by central nervous system amines.
Physalaemin's action involves the hypothalamic-pituitary-thyroid axis and is influenced by neurotransmitter systems.

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