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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
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In vitro atomization analysis and evaluation of inhalable sodium sivelestat formulations
Rangdong Liu1,2,3, Aifang He3, Yan Xu3
1Zhuhai College of Science and Technology, Zhuhai, China.
Plos One
|September 20, 2024
Summary
This study demonstrates that self-developed sodium sivelestat is suitable for aerosol inhalation. Inhalation therapy showed equal effectiveness to injection for acute lung injury in mice.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Respiratory Medicine
Background:
- Sodium sivelestat is a potential therapeutic agent for respiratory conditions.
- Developing effective inhalation formulations is crucial for targeted lung delivery.
- Current delivery methods may have limitations in efficacy or administration.
Purpose of the Study:
- To assess the in vitro atomization properties of a novel sodium sivelestat formulation for inhalation.
- To evaluate the feasibility of this preparation as an aerosolized drug.
- To guide subsequent animal studies on its efficacy.
Main Methods:
- Atomization performance was evaluated by measuring fine particle mass and total emitted dose.
- Comparative analysis of atomization characteristics between air-compressed and mesh nebulizers.
- In vivo efficacy testing using a mouse model of acute lung injury induced by lipopolysaccharide inhalation.
Main Results:
- The developed sodium sivelestat formulation met inhalation requirements for atomization parameters.
- Mesh nebulizers demonstrated superior performance with smaller and more uniform particle size distribution.
- Inhaled sodium sivelestat was equally effective as injected sodium sivelestat at lower concentrations in treating acute lung injury.
Conclusions:
- The self-developed sodium sivelestat formulation is feasible for aerosol inhalation.
- Inhalation offers a potentially more efficient and effective route for sodium sivelestat delivery.
- This formulation shows promise as an inhaled therapeutic for acute lung injury.
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