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Related Experiment Video

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Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
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Carbon Dots Crosslinked Egg White Hydrogel for Tissue Engineering.

Jun Wu1,2,3, Josh Haipeng Lei3,4, Moxin Li3,4

  • 1Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Macau, 999078, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|September 20, 2024
PubMed
Summary
This summary is machine-generated.

Carbon dots (CDs) enhance egg white (EW) hydrogels for tissue engineering. The resulting CDs-crosslinked EW hydrogel (CEWH) shows improved integration and degradation, promoting hair follicle regeneration and wound healing.

Keywords:
carbon dotsegg whitehair follicle regenerationprotein hydrogelswound healing

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Egg white (EW)-derived hydrogels are promising for in vitro cell culture due to their extracellular matrix-mimicking properties.
  • Highly cross-linked EW hydrogels have limitations for in vivo applications due to poor dynamic tissue integration before degradation.

Purpose of the Study:

  • To address the limitations of EW hydrogels for in vivo applications by introducing carbon dots (CDs) as cross-linking agents.
  • To develop a CDs-crosslinked EW hydrogel (CEWH) with enhanced properties for tissue engineering and regenerative medicine.

Main Methods:

  • EW was cross-linked using CDs in a dilute aqueous solution to form CEWH.
  • The mechanical properties, pore structure, and degradation rate of CEWH were evaluated.
  • Subcutaneous implantation of CEWH was performed to assess tissue integration and biological effects.

Main Results:

  • CEWH exhibited tensile strength comparable to skin tissue and a large pore structure facilitating cell infiltration.
  • Subcutaneous implantation showed excellent tissue integration and a degradation rate synchronized with the hair follicle (HF) regeneration cycle.
  • CEWH promoted an M2 macrophage-dominated immune microenvironment, stimulating HF regeneration from telogen to anagen phase and demonstrating wound dressing potential.

Conclusions:

  • CEWH overcomes the limitations of native EW hydrogels, offering superior in vivo integration and controlled degradation.
  • The study demonstrates the potential of CEWH for promoting hair follicle regeneration and serving as an effective wound dressing.
  • EW, modified with CDs, presents a versatile biomaterial platform for diverse tissue engineering applications.