TRP channels in cancer: Therapeutic opportunities and research strategies

Area of Science:

• Gastroenterology
• Oncology
• Microbiology
• Pharmacology

Background:

• Gut microbiota's role in gastrointestinal conditions via transient receptor potential (TRP) channels is known.
• The specific involvement of TRP channels in cancer progression remains less understood.
• TRP channels are crucial regulators of cellular functions implicated in oncogenesis.

Purpose of the Study:

• To review the multifaceted roles of TRP channels in cancer progression and therapeutic outcomes.
• To investigate the influence of traditional medicines, particularly traditional Chinese medicine (TCM) aromatic medicines, on TRP channel functions in cancer.
• To explore the interplay between gut microbiota and TRP channels in cancer signaling and therapeutic potential.

Main Methods:

• Literature review focusing on TRP channels, gut microbiota, and cancer.
• Analysis of the impact of traditional medicines on TRP channel activity.
• Examination of current therapeutic modalities' effects on TRP channels in cancer.
• Discussion of technological advancements like artificial intelligence (AI) and computer-aided drug development (CADD).

Main Results:

• TRP channels play significant roles in oncogenesis, cancer progression, and treatment responses.
• Gut microbiota modulates TRP channel function, impacting cancer signaling pathways.
• Traditional medicines, including TCM aromatic medicines, show potential in influencing TRP channel activity for therapeutic benefit.
• Current cancer therapies can affect TRP channel function, necessitating a nuanced understanding.

Conclusions:

• Targeting the gut microbiota-TRP channel axis presents a promising therapeutic strategy for cancer treatment.
• Integrating AI and CADD can accelerate the development of novel TRP channel-based cancer therapies.
• Further research into TRP channels is essential for advancing cancer treatment and improving patient outcomes.