Related Experiment Video
Updated: Jun 13, 2025
07:20
Author Spotlight: Epigenetic Modifications and Metabolic Rewiring as Targets for Cancer Therapy
Published on: October 18, 2024
482
Histone methyltransferase KMT2A: Developmental regulation to oncogenic transformation
1Division of Pediatric Hematology-Oncology, Children's Hospital Los Angeles, Los Angeles, California, USA; Department of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
The Journal of Biological Chemistry
|September 20, 2024
Summary
Dr. C. David Allis
Area of Science:
- Epigenetics and molecular biology.
- Cancer biology and therapeutics.
Background:
- Epigenetic regulation is crucial for development and disease.
- The KMT2A (MLL1) gene's lysine methyltransferase activity was first characterized in 2002.
- KMT2A mutations are implicated in numerous human diseases.
Purpose of the Study:
- To review the current understanding of KMT2A's roles in development and disease.
- To highlight KMT2A's significance in human pathologies.
- To discuss emerging cancer therapies targeting KMT2A.
Main Methods:
- Literature review of KMT2A research.
- Analysis of KMT2A's functions in biological processes.
- Examination of KMT2A's involvement in disease pathogenesis.
Main Results:
- KMT2A plays multifaceted roles in development.
- KMT2A dysregulation is linked to various human diseases.
- KMT2A is a target for novel cancer therapies.
Conclusions:
- KMT2A is a key player in epigenetic regulation.
- Understanding KMT2A's functions is vital for disease treatment.
- Targeting KMT2A offers promising therapeutic strategies for cancer.
More Related Videos
10:09Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
Published on: January 26, 2018
7.4K
06:07Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
Published on: August 5, 2022
2.5K
Related Concept Videos
01:37Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
02:32Histone Modification
13.2K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
13.2K
02:25Spreading of Chromatin Modifications
8.2K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
Writers
The writer...
8.2K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
02:23Master Transcription Regulators
6.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K