Postnatally overfed mice display cardiac function alteration following myocardial infarction
Marie Josse1, Eve Rigal1, Nathalie Rosenblatt-Velin2
1Research Team: Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2), Université de Bourgogne, Faculté des Sciences de Santé, 7 Bd Jeanne d'Arc, 21000 Dijon, France.
Biochimica Et Biophysica Acta. Molecular Basis of Disease
|September 20, 2024
Summary
Postnatal overfeeding in mice worsens cardiac function after heart attack, indicating potential early heart failure. This metabolic syndrome model impacts cardiovascular health and recovery.
Area of Science:
- Cardiology
- Metabolic Syndrome Research
- Animal Models of Disease
Background:
- Cardiovascular diseases are a leading global cause of mortality.
- Metabolic syndrome is linked to cardiovascular pathologies and comorbidities like obesity and hypertension.
- An innovative mouse model of metabolic syndrome induced by postnatal overfeeding (PNOF) was developed.
Purpose of the Study:
- To investigate the impact of PNOF on cardiac remodeling.
- To evaluate the development of heart failure following myocardial infarction (MI) in the PNOF model.
Main Methods:
- Male C57BL/6 mice were assigned to normally-fed (NF) or PNOF groups based on litter size.
- Mice underwent myocardial infarction (MI) induction at 4 months of age.
- Echocardiography and biomolecular analyses were performed up to 6 months post-MI.
Main Results:
- PNOF mice showed increased body weight, reduced ejection fraction, and larger end-systolic area at baseline.
- Post-MI, PNOF mice exhibited decreased stroke volume, increased heart rate, and reduced cardiac output.
- No significant differences in cardiac/lung mass, fibrosis, or mRNA expression were observed between NF-MI and PNOF-MI groups at 6 months.
Conclusions:
- PNOF mice demonstrate worsened cardiac function post-MI, with decreased cardiac output.
- These findings suggest PNOF may indicate early signs of heart failure decompensation.
- The PNOF model provides insights into metabolic syndrome's impact on cardiac recovery.
