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Updated: Jun 12, 2025

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Relmapirazin, a new exogenous filtration marker, and more widespread use of measured GFR
Marcelle Tuttle1, Andrew S Levey1
1Division of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA.
Abstract:
Plasma or urinary clearance of exogenous filtration markers is required for assessment of measured glomerular filtration rate. Although multiple methods are available, none is widely used because of their complexity, each has measurement error, and standardization is limited. Recently, a study validated the plasma clearance of a new exogenous filtration marker, relmapirazin, which can be detected by its transdermal fluorescence, potentially simplifying the procedure and increasing access to measured glomerular filtration rate.
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