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Updated: Jun 12, 2025

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

Engineering next generation vascularized organoids.

Nicolas Werschler¹, Clement Quintard², Stephanie Nguyen³

¹University of British Columbia, Life Sciences Institute, Vancouver, Canada; University of British Columbia, School of Biomedical Engineering, Vancouver, Canada.

Atherosclerosis

|September 20, 2024

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Organoid models, used to study human development and disease, now incorporate perfusable blood vessels. This advancement significantly improves their physiological relevance for research and drug development.

Area of Science:

Biomedical Engineering
Developmental Biology
Tissue Engineering

Background:

Organoids are self-organizing 3D cell cultures that mimic human organ structure and function in vitro.
Current organoid models often lack a functional vascular component, limiting their physiological relevance.
Advancements in organoid generation aim to improve in vivo resemblance.

Purpose of the Study:

To discuss methods for creating perfusable blood vessel networks within organoid systems.
To highlight the importance of vascularization for enhancing organoid models.

Main Methods:

Review of methodological approaches for generating vascularized organoids.
Focus on techniques enabling perfusable blood vessel networks.

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Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

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Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

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Last Updated: Jun 12, 2025

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

Published on: January 20, 2023

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Main Results:

Successful integration of perfusable vascular compartments into organoid systems.
Demonstration of enhanced physiological relevance through vascularization.

Conclusions:

Incorporating perfusable vasculature is crucial for next-generation organoid systems.
Vascularized organoids offer improved models for developmental studies, clinical research, and drug discovery.