Defining an ageing-related pathology, disease or syndrome: International Consensus Statement

Area of Science:

• Gerontology and Ageing Research
• Pathology and Disease Classification
• Public Health and Healthcare Policy

Background:

• Global populations are aging, leading to increased lifespans but not necessarily improved health spans.
• Ageing-related diseases significantly impact health status, functional capacity, and quality of life.
• Comprehensive classification and staging systems are vital for addressing the needs of aging populations.

Purpose of the Study:

• To establish consensus-based criteria for defining ageing-related pathologies, diseases, and syndromes.
• To provide a foundation for developing robust classification and staging systems for age-related conditions.
• To guide the development and utilization of interventions aimed at preventing or mitigating age-related decline.

Main Methods:

• A consensus meeting was convened by the International Consortium to Classify Ageing-Related Pathologies (ICCARP) on February 19, 2024, in Cardiff, UK.
• 150 recognized experts debated and voted on provisional criteria for defining ageing-related pathologies.
• A consensus agreement of ≥70% was required for the approval of each criterion.

Main Results:

• Three core criteria for an ageing-related pathology, disease, or syndrome were agreed upon.
• Criterion 1: Develops and/or progresses with increasing chronological age.
• Criterion 2: Associated with or contributes to functional decline or increased susceptibility to it.
• Criterion 3: Evidenced by studies in humans.

Conclusions:

• Consensus criteria for ageing-related pathologies, diseases, and syndromes have been established by an international expert consortium.
• These agreed-upon criteria will be utilized by ICCARP for future classification and staging efforts.
• The established criteria provide a standardized framework for understanding and addressing age-related health challenges.