Related Experiment Video

Updated: May 2, 2026

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions
11:58

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

Published on: October 18, 2017

9.3K

Efficacy of Amorolfine in Onychomycosis Treatment: A Mixed-Effects Models and Multivariate Logistic Regression

Chichi Du1,2, Mingming Ding3, Lin Zhang1,2

  • 1Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Mycoses
|September 20, 2024
PubMed
Abstract

Insights

Amorolfine nail lacquer concentrations in nails vary by patient and nail characteristics, impacting treatment efficacy for onychomycosis (OM). Dermoscopy effectively monitors treatment success in this common fungal infection.

Area of Science:

  • Dermatology
  • Mycology
  • Pharmacokinetics

Background:

  • Onychomycosis (OM) is a prevalent nail fungal infection.
  • Amorolfine hydrochloride nail lacquer is a common treatment in China.
  • Monitoring drug levels and using dermoscopy can enhance understanding of OM treatment.

Purpose of the Study:

  • To analyze amorolfine concentrations in nails with mild to moderate OM.
  • To assess treatment outcomes using dermoscopy.
  • To explore factors influencing drug concentrations and treatment efficacy.

Main Methods:

  • Patients with mild to moderate OM underwent treatment with amorolfine nail lacquer (twice weekly for 36 weeks).
  • Monthly nail samples were analyzed for amorolfine concentrations via liquid chromatography.
  • Dermoscopy was used for pre- and post-treatment evaluation.

Main Results:

  • Amorolfine concentrations increased over time, with higher levels observed in females, fingernails, specific digits, and superficial white OM.
  • Higher drug concentrations and specific OM types were associated with better clinical efficacy.
  • Peak amorolfine concentration positively correlated with clinical and mycological treatment responses.

Conclusions:

  • Amorolfine concentrations are influenced by patient and nail-specific factors, affecting treatment outcomes.
  • Dermoscopy is a valuable tool for monitoring the efficacy of onychomycosis treatment.
  • Fungal cultures were not performed, and the study had limitations including sample size and follow-up duration.
Keywords:
amorolfine hydrochloridedermoscopymixed‐effects modellingonychomycosis

More Related Videos

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.3K
Automation of Bio-Atomic Force Microscope Measurements on Hundreds of C. albicans Cells09:27

Automation of Bio-Atomic Force Microscope Measurements on Hundreds of C. albicans Cells

Published on: April 2, 2021

3.9K

Related Concept Videos

Pharmacodynamic Models: Emax Drug–Concentration Effect Model01:18

Pharmacodynamic Models: Emax Drug–Concentration Effect Model

The Emax drug-concentration effect model is central to pharmacodynamics in drug discovery and development. This model is predicated on the receptor occupancy theory, which posits that the effect of a drug is directly related to the number of receptors occupied by the drug and the resultant complex formation.The model describes the reversible interaction between a drug (C) and a receptor (R) to form a drug-receptor complex (RC). The kinetics of this interaction are quantified by an equation that...
240
Pharmacodynamic Models: Linear Concentration–Effect Model01:15

Pharmacodynamic Models: Linear Concentration–Effect Model

The linear concentration–effect model, underpinned by the principle that pharmacological effect (E) is directly proportional to plasma drug concentration (C), emerges as a pivotal simplification of the Emax model for conditions where C is significantly less than EC50. This model portrays a linear trajectory of the concentration–effect relationship when drug levels are markedly below the EC50 threshold.Despite its inherent assumption of continuous effect augmentation with increasing...
91
Pharmacodynamic Models: Logarithmic Concentration–Effect Model01:15

Pharmacodynamic Models: Logarithmic Concentration–Effect Model

The log-linear model is a pharmacological framework used to describe the relationship between drug concentration and its effect. This model is particularly relevant when the observed effects range between 20% and 80% of the drug’s maximum effect (Emax), where a near-linear relationship is observed between the log of drug concentration and the measured effect. However, the log-linear model does not predict the maximum possible effect (Emax) or the effect at zero drug concentration,...
109
Pharmacodynamic Models: Additive and Proportional Drug Effect Model01:09

Pharmacodynamic Models: Additive and Proportional Drug Effect Model

Drug response models describe how pharmacological agents interact with biological systems to produce measurable effects. Baseline responses are inherent physiological activities without a drug significantly influencing the observed pharmacological outcomes. Depending on the drug response model employed, these baseline responses may combine with the drug's effect in either an additive or proportional manner.Additive Drug Response ModelIn the additive model, the drug effect is independent of the...
119
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure...
97
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
119