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Clonidine in prophylaxis of migraine
Acta Neurologica Scandinavica
|October 1, 1979
Summary
Clonidine hydrochloride, an antihypertensive drug, was studied for migraine prevention. This trial found no significant difference between clonidine and placebo in reducing migraine attack frequency, with no observed side effects.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine is a common neurological disorder characterized by recurrent attacks.
- Various medications are used to reduce migraine frequency.
- Clonidine hydrochloride, an antihypertensive agent, has shown potential efficacy for migraine prophylaxis.
Purpose of the Study:
- To evaluate the efficacy of clonidine hydrochloride in reducing the frequency of migraine attacks.
- To assess the safety profile of clonidine hydrochloride in migraine patients.
Main Methods:
- A double-blind, cross-over trial was conducted.
- Twenty patients diagnosed with migraine participated in the study.
- Patients received either clonidine hydrochloride or a placebo, with a crossover period.
Main Results:
- Statistical analysis using the Wilcoxon non-parametric test revealed no significant difference in attack frequency reduction between clonidine and placebo.
- No adverse side effects associated with clonidine hydrochloride were reported during the trial.
Conclusions:
- Clonidine hydrochloride did not demonstrate statistically significant efficacy in reducing migraine attack frequency compared to placebo in this study.
- Further research may be needed to explore the potential role of clonidine or its mechanism of action in migraine management.