Clinical value of peripheral blood miR-21 and miR-486 combined with CT forearly cancer diagnosis in pulmonary nodulessmoking

Zheng Wang ¹, Jinfeng Liu ¹, Qiang Liu ¹

⁰Department of Thoracic Surgery, The First Hospital of Hebei Medical University, No. 89, Donggang Road, Shijiazhuang, 050000, Hebei, China.

Journal of Cardiothoracic Surgery +

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September 20, 2024

View abstract on PubMed

Summary

Combining peripheral blood microRNAs (miRNAs) miR-21 and miR-486 with CT scans shows promise for early lung nodule cancer detection. This approach enhances diagnostic accuracy for pulmonary nodules in smokers.

Area Of Science

Biomarker discovery
Molecular diagnostics
Pulmonary medicine

Background

Early diagnosis of lung cancer in pulmonary nodules is crucial for patient outcomes.
Current diagnostic methods may have limitations in specificity and sensitivity.
Identifying reliable biomarkers can improve early detection rates.

Purpose Of The Study

To evaluate the clinical significance of combining peripheral blood miR-21 and miR-486 with CT scans for early cancer diagnosis in pulmonary nodules.
To assess the diagnostic performance of these microRNAs in distinguishing malignant from benign pulmonary nodules.
To explore the potential of these biomarkers in a smoking population at risk for lung cancer.

Main Methods

A study involving 215 patients with isolated pulmonary nodules and 30 healthy smokers (control group).
Analysis of plasma expression levels of miR-21, miR-486, and miR-210.
Utilizing chest CT scans for nodule detection and classification.
Employing training and verification sets for robust evaluation.

Main Results

Plasma miR-210 levels were significantly higher in patients with benign pulmonary nodules compared to controls.
Plasma miR-486-5p levels were lower in patients with malignant nodules versus benign nodules.
The combination of miR-21 and miR-486 demonstrated a high diagnostic accuracy (AUC of 0.865) for lung cancer in pulmonary nodules.

Conclusions

Peripheral blood miR-21 and miR-486, when combined with CT scans, show potential as non-invasive biomarkers for early lung cancer diagnosis.
These microRNAs may aid in differentiating malignant from benign pulmonary nodules.
Further validation is warranted to establish their role in clinical practice for lung nodule management.

Keywords:

Early CT diagnosis Peripheral blood Pulmonary nodules miR-21 and miR-486