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L-PRF in extra-oral wound care
Nelson Pinto1,2,3, Jize Yu4,5, Sushil Koirala6
1Center of Translational Medicine, Faculty of Medicine, Universidad de la Frontera, Temuco, Chile.
Abstract:
Leukocyte- and platelet-rich fibrin (L-PRF), a by-product of centrifuged autologous whole blood, contains high concentrations of platelets, leukocytes, and fibrin (the latter spontaneously creating a strong 3-D network (a membrane)). L-PRF membranes possess several characteristics essential in wound healing, including a barrier function, an antibacterial and analgesic activity, and the release of growth factors enhancing tissue regeneration and neo-vasculogenesis. This review investigated the role of L-PRF in treating non-responding chronic wounds such as diabetic foot, venous leg ulcers, pressure ulcers, complex wounds, leprosy ulcers (Hansen's Disease), and other demanding wounds. Chronic wounds affect millions worldwide, negatively impacting their quality of life, productivity, and life expectancy while incurring high treatment costs for themselves and private and public health systems. L-PRF has demonstrated clear adjunctive advantages in treating chronic skin wounds, shortening the time to complete wound closure, and improving patient-reported outcome measures (including reducing pain and minimizing the need for analgesics). Also, in other demanding wounds, L-PRF facilitates healing. To help clinicians, this article also proposes recommendations for the use of L-PRF in the treatment of extra-oral wounds.
Insights
Leukocyte- and platelet-rich fibrin (L-PRF) membranes accelerate healing in chronic wounds like diabetic foot and venous ulcers. This regenerative biomaterial offers a barrier function and growth factor release, improving patient outcomes and reducing pain.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Wound Healing Research
Background:
- Chronic wounds pose a significant global health burden, impacting patient quality of life and healthcare costs.
- Leukocyte- and platelet-rich fibrin (L-PRF) is an autologous biomaterial derived from centrifuged blood.
- L-PRF membranes exhibit properties beneficial for tissue repair, including barrier function, antimicrobial activity, and growth factor release.
Purpose of the Study:
- To review the efficacy of L-PRF in managing non-responding chronic wounds.
- To evaluate L-PRF's role in treating various challenging wound types.
- To provide clinical recommendations for L-PRF application in extra-oral wound treatment.
Main Methods:
- Systematic review of existing literature on L-PRF for chronic wound treatment.
- Analysis of studies focusing on diabetic foot ulcers, venous leg ulcers, pressure ulcers, and other complex wounds.
- Inclusion of data on L-PRF's impact on healing time and patient-reported outcomes.
Main Results:
- L-PRF demonstrates significant adjunctive benefits in accelerating the closure of chronic skin wounds.
- Treatment with L-PRF improves patient-reported outcomes, including pain reduction and decreased analgesic use.
- L-PRF facilitates healing in various demanding wound types, supporting tissue regeneration and neovascularization.
Conclusions:
- L-PRF is an effective adjunctive therapy for non-responding chronic wounds, enhancing healing and patient well-being.
- The regenerative properties of L-PRF make it a valuable tool for clinicians treating complex and chronic wounds.
- Recommendations are provided for the clinical application of L-PRF in extra-oral wound management.
