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Related Concept Videos

Hand hygiene01:23

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...

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Related Experiment Video

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L-PRF in extra-oral wound care.

Nelson Pinto1,2,3, Jize Yu4,5, Sushil Koirala6

  • 1Center of Translational Medicine, Faculty of Medicine, Universidad de la Frontera, Temuco, Chile.

Periodontology 2000
|September 21, 2024
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Summary

Leukocyte- and platelet-rich fibrin (L-PRF) membranes accelerate healing in chronic wounds like diabetic foot and venous ulcers. This regenerative biomaterial offers a barrier function and growth factor release, improving patient outcomes and reducing pain.

Keywords:
chronic non‐healing ulcerdiabetic foot ulcerextra‐oral woundleprosy ulcerleukocyte‐ and platelet‐rich fibrinpressure ulcervenous leg ulcer

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Wound Healing Research

Background:

  • Chronic wounds pose a significant global health burden, impacting patient quality of life and healthcare costs.
  • Leukocyte- and platelet-rich fibrin (L-PRF) is an autologous biomaterial derived from centrifuged blood.
  • L-PRF membranes exhibit properties beneficial for tissue repair, including barrier function, antimicrobial activity, and growth factor release.

Purpose of the Study:

  • To review the efficacy of L-PRF in managing non-responding chronic wounds.
  • To evaluate L-PRF's role in treating various challenging wound types.
  • To provide clinical recommendations for L-PRF application in extra-oral wound treatment.

Main Methods:

  • Systematic review of existing literature on L-PRF for chronic wound treatment.
  • Analysis of studies focusing on diabetic foot ulcers, venous leg ulcers, pressure ulcers, and other complex wounds.
  • Inclusion of data on L-PRF's impact on healing time and patient-reported outcomes.

Main Results:

  • L-PRF demonstrates significant adjunctive benefits in accelerating the closure of chronic skin wounds.
  • Treatment with L-PRF improves patient-reported outcomes, including pain reduction and decreased analgesic use.
  • L-PRF facilitates healing in various demanding wound types, supporting tissue regeneration and neovascularization.

Conclusions:

  • L-PRF is an effective adjunctive therapy for non-responding chronic wounds, enhancing healing and patient well-being.
  • The regenerative properties of L-PRF make it a valuable tool for clinicians treating complex and chronic wounds.
  • Recommendations are provided for the clinical application of L-PRF in extra-oral wound management.