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Updated: Jun 12, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Application of Difluoromethyl Isosteres in the Design of Pesticide Active Molecules
Wanjie Zhang1, Pengxiang Guo1, Yannian Zhang1
1Engineering Research Center of Pesticide of Heilongjiang Province, Heilongjiang University, Harbin 150080, China.
Abstract:
Difluoromethyl (CF2H) groups have been found in many listed pesticides due to their unique physical and chemical properties and outstanding biological activity. In pesticide molecules, compared with the drastic changes brought by trifluoromethyl, difluoromethyl usually moderately regulates the metabolic stability, lipophilicity, bioavailability, and binding affinity of compounds. Therefore, difluoromethylation has become an effective means to modify the biological activity of pesticide molecules. This paper reviews the representative literatures and patents containing difluoromethyl groups in the past 10 years, and introduces the research progress. The aim is to provide an effective reference value for the study of difluoromethyl in pesticides.
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