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Akkermansia in the gastrointestinal tract as a modifier of human health

Maria E Panzetta1, Raphael H Valdivia1

  • 1Department of Integrative Immunobiology, Duke University, Durham, NC, USA.

Gut Microbes
|September 21, 2024
PubMed

Insights

Akkermansia bacteria in the gut microbiota influence health across various body systems. Their impact, whether beneficial or detrimental, depends on host genetics, bacterial strain properties, and interactions with other microbes.

Area of Science:

  • Microbiome research
  • Gut health
  • Human microbiota

Background:

  • Akkermansia species are common in the human gut microbiome.
  • Akkermansia muciniphila abundance is linked to human and animal health and disease.
  • The gastrointestinal tract harbors Akkermansia species with potential health implications.

Purpose of the Study:

  • To review the association between Akkermansia species in the GI tract and health outcomes.
  • To explore the spectrum of disorders influenced by Akkermansia.
  • To discuss the mechanisms underlying Akkermansia's health effects.

Main Methods:

  • Literature review of studies on Akkermansia and health outcomes.
  • Analysis of findings across digestive, respiratory, urinary, and central nervous systems.
  • Synthesis of factors influencing Akkermansia's health impact.

Main Results:

  • Akkermansia species are implicated in health outcomes across multiple organ systems.
  • The effects of Akkermansia vary depending on numerous host and microbial factors.
  • Disorders affecting the digestive, respiratory, urinary, and central nervous systems are discussed in relation to Akkermansia.

Conclusions:

  • The health impact of Akkermansia is context-dependent.
  • Host genetics, strain characteristics, and microbiota interactions modulate Akkermansia's effects.
  • Further research is needed to fully elucidate the complex role of Akkermansia in health and disease.
Keywords:
ADALSASDAkkermansia muciniphilaCKDClostridium difficileGVHDIBDLCMVMSNAFLDPDSalmonella typhimuriumasthmabiwaensiscancerdiabetesdurhamiiepilepsyhelminthignisimmunotherapyinfectionsinfluenzalivermassiliensismicrobiotanephropathyneurological diseaseobesitysepsistuberculosis

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