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Related Experiment Video

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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
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Resting-state functional connectivity abnormalities in subjective cognitive decline: A 7T MRI study.

M Pievani1, F Ribaldi2, K Toussas3

  • 1Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Neurobiology of Aging
|September 21, 2024
PubMed
Summary
This summary is machine-generated.

Subjective cognitive decline (SCD) individuals show altered brain connectivity. Higher functional connectivity (FC) in specific networks is linked to poorer cognition, suggesting it

Keywords:
7T MRIHuman brain networksIntrinsic functional connectivitySubjective cognitive decline

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Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Geriatric Medicine

Background:

  • Resting-state functional connectivity (FC) MRI detects early Alzheimer's disease (AD) changes.
  • Studies on FC in subjective cognitive decline (SCD) yield conflicting results.
  • No 7 Tesla (7T) MRI studies have investigated FC in SCD.

Purpose of the Study:

  • To investigate functional connectivity (FC) alterations in individuals with SCD using 7T fMRI.
  • To assess the association between FC in canonical brain networks and cognitive/clinical features in SCD.

Main Methods:

  • Sixty-six participants (24 controls, 14 SCD, 28 cognitively impaired [CI]) were recruited.
  • Participants underwent 7T fMRI to evaluate FC in default mode network (DMN) and ventral attention network (VAN).
  • Cognitive assessments, clinical evaluations, and AD biomarker analysis were performed.

Main Results:

  • SCD participants exhibited normal cognition and AD biomarkers, with a trend for higher depressive symptoms.
  • Compared to controls and CI groups, SCD individuals showed increased FC in frontal DMN and VAN nodes.
  • Elevated FC in DMN and VAN correlated with poorer cognitive performance, independent of depressive symptoms.

Conclusions:

  • Hyper-connectivity in the DMN and VAN may represent a signature of age-related cognitive decline in SCD.
  • These findings suggest potential utility of 7T fMRI for characterizing early cognitive changes in at-risk individuals.
  • SCD individuals with higher FC may have a lower risk of progressing to Alzheimer's disease.