Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

High-Performance Liquid Chromatography: Types of Detectors

High-Performance Liquid Chromatography: Types of Detectors

The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Construction of Nitrogen-rich Graphene Oxide/Chitosan Adsorbent for the Removal of Hexavalent Chromium from Wastewater.

Journal of separation science·2026

Same author

1D Fully sp<sup>2</sup> Carbon-Linked Covalent Organic Frameworks for Powerful Photoreduction of CO<sub>2</sub>.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

Impact of integrating body and organ donation education into anatomy teaching on medical students' concepts of respect for life: a mixed-methods cluster randomized trial.

BMC medical education·2026

Same author

A cysteine reactive chloroalkane probe enables HaloTag ligation for downstream chemical proteomics analysis.

RSC chemical biology·2026

Same author

Predicting the number of care beds for older people by a novel grey Verhulst cosine self-memory model: two case studies of Jiangsu and Shanghai, China.

BMC geriatrics·2026

Same author

Fusobacterium nucleatum alleviates alcohol-associated liver disease through mannose-mediated elevation of Fbp1 and modulation of gut microbiota.

Journal of hepatology·2026

Search research articles

Related Experiment Video

Updated: Jun 12, 2025

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

Active-matrix extended-gate field-effect transistor array for simultaneous detection of multiple metabolites.

Chaochao Shen¹, Xin Xi¹, Dongqing Wu²

¹Department of Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

Biosensors & Bioelectronics

|September 21, 2024

Summary

This study presents an active-matrix extended-gate field-effect transistor (AMEGFET) array for instant metabolite analysis in body fluids. This technology supports personalized healthcare by enabling rapid, multiplexed biomarker detection for disease monitoring.

Keywords:

Active-matrix Electrochemical biosensors Extended-gate field-effect transistor array Multiple-metabolite detection Simultaneous sensing systems

More Related Videos

A Multi-detection Assay for Malaria Transmitting Mosquitoes

A Multi-detection Assay for Malaria Transmitting Mosquitoes

Published on: February 28, 2015

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Related Experiment Videos

Last Updated: Jun 12, 2025

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

A Multi-detection Assay for Malaria Transmitting Mosquitoes

A Multi-detection Assay for Malaria Transmitting Mosquitoes

Published on: February 28, 2015

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Area of Science:

Biomedical Engineering
Nanotechnology
Analytical Chemistry

Background:

Personalized healthcare and precise diagnosis require sensitive, specific, and rapid monitoring of multiple metabolites.
Existing biological sensing systems often face limitations in throughput and instant analysis capabilities for complex body fluid samples.

Purpose of the Study:

To develop an active-matrix extended-gate field-effect transistor (AMEGFET) array for simultaneous, instant analysis of various metabolites.
To demonstrate the potential of this array for personalized healthcare and proactive disease management.

Main Methods:

Fabrication of an AMEGFET array with extended gate electrodes functionalized with oxidoreductase enzymes and platinum nanoparticles.
Utilizing ordered mesoporous carbon fibers for enhanced electrode performance.
Employing customized electrode combinations for multiplexed metabolite detection.

Main Results:

The AMEGFET array successfully performed instant analysis of multiple metabolites including glucose, uric acid, cholesterol, ethanol, and lactate from small body fluid volumes.
The integrated switch function simplified readout circuitry and prevented inter-unit interference in large-scale arrays.
Demonstrated high flexibility and scalability for high-throughput biomarker sensing.

Conclusions:

The developed AMEGFET array offers a promising high-throughput sensing platform for proactive health and intelligent healthcare.
This technology provides efficient technical support for monitoring metabolites linked to chronic diseases and lifestyle factors.
The system's capabilities align with the growing demand for personalized medicine and precise diagnostics.