Research diversity and advances in simultaneous removal of multi-mycotoxin

Mycotoxins are toxic secondary metabolites produced by different fungal species under specific environmental conditions. The common and regulated mycotoxins are such as deoxynivalenol (DON), zearalenone (ZEN), ochratoxin (OTA), aflatoxin B₁ (AFB₁), and fumonisins (FB). These mycotoxins are highly regulated in feed and food because their effects start to exert from their lowest exposures and are abundant in our common environment. However, there are other emerging mycotoxins such as apicidin, beauvericin, aurofusarin, and enniatins which are also harmful. Thus, making a total of around 500 forms of mycotoxins. The existence of mycotoxins in feed and food has a significant impact on animal and human health, which ultimately, slows down economic growth globally. According to this review, different approaches to removing multi-mycotoxin separately or simultaneously have been stated. Mostly, the review focused on the simultaneous removal of different multiple mycotoxins. This is because the current studies show a growing trend in reporting the co-existence of multiple mycotoxins in feed and food materials, however, most detoxifying approaches are for singular mycotoxins. Therefore, the physical, chemical, and biological approaches to remove multi-mycotoxin have been elucidated as well as their advantages and limitations. Furthermore, the authors give suggestions on the way forward to reduce exposure to mycotoxins and diminish their health effects in society. Lastly, the authors emphasized introducing more stringent limits for co-existing mycotoxins, especially those that have the same health effects by acting synergistically, such as AFB₁ and OTA, which both act as carcinogenic agents.