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Updated: Jun 12, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
The relationship between ceramide profile and residual inflammatory risk in patients with coronary artery disease:
Liang Zhang1, YaoDong Ding2, MingHui Chen3
1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China (Drs Zhang, Ding and Zeng); Department of Cardiology, Beijing Chest Hospital, Capital Medical University, Beijing, China (Dr Zhang and Gao).
Insights
Elevated plasma ceramide Cer (d18:1/16:0) levels are linked to higher residual inflammatory risk in coronary artery disease patients. This specific ceramide may serve as a key biomarker for managing cardiovascular disease.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
- Inflammation Research
Background:
- Cardiovascular disease (CVD) remains a leading global cause of death.
- While cholesterol management has advanced, targeting inflammation is crucial for reducing residual cardiovascular risk.
- This study investigates the link between plasma ceramides and residual inflammatory risk in coronary artery disease (CAD).
Purpose of the Study:
- To explore the association between plasma ceramide levels and residual inflammatory risk in patients with CAD.
- To identify specific ceramides that may serve as biomarkers for elevated inflammation in CAD.
- To determine if plasma ceramides are independent predictors of residual inflammatory risk.
Main Methods:
- Cross-sectional observational design using data from a Chinese multicenter prospective cohort study.
- Patients were stratified into low and high residual inflammatory risk groups based on hsCRP levels (≥2.0 mg/L).
- Plasma ceramide levels were quantified using LC-MS/MS, with statistical analyses including logistic regression to assess associations.
Main Results:
- A total of 778 CAD patients were analyzed.
- Specific plasma ceramides, including Cer (d18:1/16:0), were significantly elevated in the high residual inflammatory risk group.
- Cer (d18:1/16:0) showed a positive correlation with hsCRP and was identified as an independent indicator of high residual inflammatory risk.
Conclusions:
- A significant association exists between plasma Cer (d18:1/16:0) and high residual inflammatory risk in CAD patients.
- This finding suggests Cer (d18:1/16:0) could be a valuable inflammatory biomarker for CVD management.
- Targeting ceramides may offer new therapeutic strategies for reducing cardiovascular risk.
Background:
Although progress has been made in managing cholesterol, targeting inflammation is essential for further reducing cardiovascular risk, as carvdiovascular disease (CVD) remains the leading cause of death globally. This study aimed to explore the association between plasma ceramide levels and residual inflammatory risk in patients with coronary artery disease (CAD).
Methods:
A cross-sectional observational design was adopted using data from a secondary analysis of a multicenter prospective cohort study in China. Patients were categorized into two groups based on a high-sensitivity C-reactive protein (hsCRP) level of 2.0 mg/L. Plasma ceramide (Cer) levels were measured using the LC-MS/MS system. By collecting and statistically analyzing patient demographic and clinical characteristics, differences were compared between the low residual inflammatory risk group (Low RIR) and the high residual inflammatory risk group (High RIR). Multivariate logistic regression analysis was used to assess the interaction of plasma ceramides with high residual inflammation risk.
Results:
A total of 778 patients with confirmed CAD were included in the study. Compared to the Low RIR, Cer (d18:1/16:0), Cer (d18:1/18:0), Cer (d18:1/20:0), Cer (d18:1/22:0), Cer (d18:1/24:0), and Cer (d18:1/24:1), were significantly elevated in the High RIR group. Spearman correlation analysis indicated that Cer (d18:1/16:0) levels were positively correlated with hsCRP. Further multivariable logistic regression analysis revealed that Cer (d18:1/16:0) was a significant independent indicator of high RIR beyond conventional cardiovascular risk factors.
Conclusion:
This study found a significant association between a specific plasma ceramide Cer (d18:1/16:0) and high residual inflammatory risk in CAD patients, suggesting it could be an important inflammatory biomarker in the management of CVD.
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