Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Male hypogonadism and scleroderma.

N S Nowlin, S H Zwillich, J E Brick

    The Journal of Rheumatology
    |June 1, 1985
    PubMed
    Summary

    This study describes two male patients with scleroderma and hypogonadism. It explores potential links between these conditions, including Klinefelter's syndrome and hormonal imbalances.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Patterns of clinical response in patients with alopecia areata treated with ritlecitinib in the ALLEGRO clinical development programme.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2025
    Same author

    Supernumerary kidney as a cause of uretero-pelvic obstruction.

    The Journal of urology·2010
    Same author

    The proven ineffectiveness of the compression bag in intravenous pyelography.

    The Journal of urology·2010
    Same author

    Polycystic disease in a solitary kidney.

    The Journal of urology·2010
    Same author

    General considerations of the treatment of renal calculi.

    Missouri medicine·2010
    Same author

    Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial.

    Annals of the rheumatic diseases·2009

    Area of Science:

    • Endocrinology
    • Rheumatology
    • Genetics

    Background:

    • Scleroderma is a chronic autoimmune disease affecting connective tissue.
    • Hypogonadism is a condition characterized by the failure of the testes to produce adequate testosterone.

    Observation:

    • Two male patients presenting with both scleroderma and hypogonadism were analyzed.
    • One patient was diagnosed with Klinefelter's syndrome (47,XXY).
    • The second patient exhibited normal testosterone levels but elevated gonadotrophins, suggesting primary hypogonadism.

    Findings:

    • The cases highlight a potential association between scleroderma and hypogonadism in men.
    • Klinefelter's syndrome was identified in one patient with scleroderma.
    • Hormonal dysregulation, indicated by elevated gonadotrophins despite normal testosterone, was observed in the other patient.

    Implications:

    • These findings suggest a possible etiological link or shared pathophysiology between scleroderma and hypogonadism.
    • Further research is warranted to elucidate the relationship between autoimmune diseases and endocrine dysfunction.
    • Understanding these connections may lead to improved diagnostic and therapeutic strategies for affected individuals.

    Related Experiment Videos