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Association between phthalates exposure and all-cause mortality among diabetic cases: A prospective study
Xu Cheng1, Shiyang Zhang1, Jun An1
1Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Environmental Pollution (Barking, Essex : 1987)
|September 22, 2024
Summary
Phthalates exposure is linked to increased all-cause mortality in male diabetes patients. Potential mechanisms involve hormonal and IL-6 pathways, highlighting sex-specific risks.
Area of Science:
- Environmental Health
- Toxicology
- Endocrinology
Background:
- Phthalates are common environmental contaminants linked to various health issues.
- Diabetes mellitus is a growing global health concern associated with increased mortality.
- Understanding the impact of environmental exposures on diabetic populations is crucial for public health.
Purpose of the Study:
- To investigate the association between phthalates exposure and all-cause mortality in diabetic individuals.
- To explore potential molecular mechanisms, including hormonal pathways and gene interactions, underlying this association.
- To determine if the association differs between males and females.
Main Methods:
- A longitudinal study followed 2806 diabetes cases from 2008-2018.
- Serum levels of six phthalates (PAEs) were measured.
- Cox models and genetic analyses (polygenic scores, SNPs) were used to assess associations and environment-gene interactions.
Main Results:
- Phthalates exposure was associated with increased all-cause mortality in male diabetic patients, but not in females.
- Specific phthalates (DMP, DiBP, DnBP, DEHP) showed significant associations in males.
- Enrichment analysis indicated PAEs-related genes are involved in hormone and IL-6 pathways, which were also modified by genetic variants.
Conclusions:
- Phthalates exposure is a risk factor for all-cause mortality in diabetic males.
- The hormonal system and IL-6-related pathways are potential molecular mechanisms mediating these effects.
- Sex-specific effects highlight the need for tailored risk assessment and prevention strategies in diabetic populations.
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