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Selenium and vitamin E stability in parenteral solutions
JPEN. Journal of Parenteral and Enteral Nutrition
|September 1, 1985
Summary
Alpha-tocopherol acetate and selenium are stable in parenteral solutions. These essential nutrients showed no significant loss when exposed to light, room temperature, or infusion, ensuring patient delivery.
Area of Science:
- Parenteral nutrition
- Nutrient stability
- Clinical pharmacy
Background:
- Parenteral nutrition requires stable essential micronutrients.
- Alpha-tocopherol acetate (vitamin E) and selenium are critical components.
- Assessing stability under clinical conditions is vital for patient care.
Purpose of the Study:
- To evaluate the stability of alpha-tocopherol acetate and selenium in parenteral solutions.
- To determine nutrient integrity during administration and storage.
- To confirm stability in common intravenous fluid mixtures.
Main Methods:
- Parenteral solutions containing alpha-tocopherol acetate and selenium were prepared.
- Samples were subjected to fluorescent lighting and room temperature.
- Stability was assessed after passage through an infusion apparatus and over a 10-week period.
Main Results:
- No significant degradation of alpha-tocopherol acetate was observed under tested conditions.
- Selenium (as selenious acid) demonstrated stability throughout the study.
- Nutrient integrity was maintained during simulated administration and storage.
Conclusions:
- Alpha-tocopherol acetate and selenium are stable in amino acid/dextrose parenteral solutions.
- These micronutrients remain stable when exposed to light, temperature variations, and infusion systems.
- Parenteral administration of alpha-tocopherol acetate and selenium is reliable with no significant nutrient loss.