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Related Experiment Videos

Selenium and vitamin E stability in parenteral solutions.

C D McGee, M G Mascarenhas, M J Ostro

    JPEN. Journal of Parenteral and Enteral Nutrition
    |September 1, 1985
    PubMed
    Summary
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    Alpha-tocopherol acetate and selenium are stable in parenteral solutions. These essential nutrients showed no significant loss when exposed to light, room temperature, or infusion, ensuring patient delivery.

    Area of Science:

    • Parenteral nutrition
    • Nutrient stability
    • Clinical pharmacy

    Background:

    • Parenteral nutrition requires stable essential micronutrients.
    • Alpha-tocopherol acetate (vitamin E) and selenium are critical components.
    • Assessing stability under clinical conditions is vital for patient care.

    Purpose of the Study:

    • To evaluate the stability of alpha-tocopherol acetate and selenium in parenteral solutions.
    • To determine nutrient integrity during administration and storage.
    • To confirm stability in common intravenous fluid mixtures.

    Main Methods:

    • Parenteral solutions containing alpha-tocopherol acetate and selenium were prepared.
    • Samples were subjected to fluorescent lighting and room temperature.

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  • Stability was assessed after passage through an infusion apparatus and over a 10-week period.

    • Main Results:

    • No significant degradation of alpha-tocopherol acetate was observed under tested conditions.
    • Selenium (as selenious acid) demonstrated stability throughout the study.
    • Nutrient integrity was maintained during simulated administration and storage.

    Conclusions:

    • Alpha-tocopherol acetate and selenium are stable in amino acid/dextrose parenteral solutions.
    • These micronutrients remain stable when exposed to light, temperature variations, and infusion systems.
    • Parenteral administration of alpha-tocopherol acetate and selenium is reliable with no significant nutrient loss.