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[Research progress in coatings with active compounds and extracts of traditional Chinese medicines for coronary
Si-Jia Lai1, Da-Yang Wang2, Bao-Fu Wang3
1Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China Beijing University of Chinese Medicine Beijing 100029, China.
Insights
Traditional Chinese medicine compounds show promise in enhancing percutaneous coronary intervention (PCI) devices to combat cardiovascular disease. These natural compounds offer multi-target benefits for reducing restenosis and thrombosis, improving PCI device innovation.
Area of Science:
- Biomedical Engineering
- Cardiovascular Medicine
- Pharmacology
Background:
- Cardiovascular diseases are a growing concern in China, with percutaneous coronary intervention (PCI) being a key treatment.
- Current PCI devices like drug-eluting stents and drug-coated balloons face challenges with restenosis and late thrombotic events.
- Effective inhibition of vascular smooth muscle cell proliferation and enhancement of endothelial cell activity are critical unmet needs.
Purpose of the Study:
- To review the application of traditional Chinese medicine (TCM) active compounds and extracts in PCI device coatings.
- To explore the potential of TCM in addressing restenosis and thrombosis after PCI.
- To provide insights into future innovations for PCI devices utilizing TCM.
Main Methods:
- Literature review focusing on TCM active compounds (e.g., paclitaxel, hirudin, curcumin) and extracts used in PCI coatings.
- Analysis of TCM combinations and their synergistic effects in preventing vascular smooth muscle cell proliferation and promoting endothelialization.
- Examination of research on TCM integrated into drug-eluting stents and drug-coated balloons.
Main Results:
- TCM active compounds and extracts demonstrate multi-target potential for cardiovascular applications.
- Combinations of TCM compounds (e.g., paclitaxel/hirudin) show enhanced efficacy in preclinical studies.
- TCM-based coatings offer a promising supplement to synthetic compounds for improved PCI device performance.
Conclusions:
- TCM active compounds and extracts represent a valuable resource for developing next-generation PCI devices.
- Further research into TCM applications can help overcome limitations of current PCI therapies.
- Integrating TCM holds significant potential for reducing cardiovascular disease burden and improving patient outcomes.
Abstract:
In recent years, the incidence and mortality rates of cardiovascular diseases in China have kept rising, with no significant reduction in disease burden observed. Percutaneous coronary intervention(PCI) is an effective approach for treating coronary artery disease. Drug-eluting stents and drug-coated balloons are currently the most common PCI devices used in clinical practice. However, challenges with restenosis and late-stage thrombotic events persist. Inhibiting the proliferation of vascular smooth muscle cells while enhancing endothelial cell activity is crucial for reducing restenosis and preventing thrombosis, and it remains a challenge in research. The active compounds and extracts of traditional Chinese medicine(TCM), particularly the combinations of active compounds in coatings, possess multi-target potential and serve as a supplement to coatings prepared from synthetic compounds. This review elucidates the application of TCM active compounds(such as arsenic trioxide, paclitaxel, hirudin, tetramethylpyrazine, emodin, oxymatrine, and curcumin), combinations of TCM active compounds(paclitaxel/hirudin, geniposide/baicalin), and TCM extracts(such as Curcumae Rhizoma extract and Tripterygium hypoglaucum extract) in the coatings for PCI devices in recent years. Furthermore, this review expounds the current challenges and future prospects in this field, giving insights into the innovation of PCI devices.
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