[A new secoiridoid from Cornus officinalis].

Area of Science:

• Phytochemistry
• Pharmacology

Context:

• Cornus officinalis (C. officinalis) is a traditional medicinal plant.
• Investigating its chemical constituents can reveal novel bioactive compounds.

Purpose:

• To isolate and identify chemical constituents from C. officinalis.
• To evaluate the anti-inflammatory potential of isolated compounds.

Summary:

• Ten compounds were isolated from C. officinalis, including a new secoiridoid, (±)-cornuscone.
• Spectroscopic methods including HR-ESI-MS and NMR were used for structural elucidation.
• (±)-cornuscone demonstrated significant anti-inflammatory activity in LPS-induced RAW264.7 cells, surpassing indomethacin.

Impact:

• Discovery of (±)-cornuscone, a novel secoiridoid with promising anti-inflammatory properties.
• Provides a scientific basis for the traditional use of C. officinalis.
• Highlights potential for developing new anti-inflammatory agents from natural sources.