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  11. [comparison On Effects Of Lycii Fructus From Different Origins On Naio_3-induced Retinal Degenerative Diseases In Mice By Multivariate Statistical Analysis]

[Comparison on effects of Lycii Fructus from different origins on NaIO_3-induced retinal degenerative diseases in mice by multivariate statistical analysis]

Xin Chen1, Sheng Guo1, Jie-Mei Wang1

  • 1National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine/Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/National Administration of Traditional Chinese Medicine Key Laboratory for Chinese Medicine Resources Recycling Utilization, Nanjing University of Chinese Medicine Nanjing 210023, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|September 22, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Lycii Fructus extracts improved vision and reduced retinal damage in mice with retinal degenerative diseases (RDD). Ningxia Lycii Fructus showed superior therapeutic effects on RDD.

Area of Science:

  • Pharmacology
  • Ophthalmology
  • Statistical Analysis

Background:

  • Retinal degenerative diseases (RDD) pose a significant threat to vision.
  • Lycii Fructus is traditionally used for various health benefits, but its efficacy for RDD from different origins requires scientific validation.
  • Establishing a robust mouse model of RDD is crucial for evaluating therapeutic interventions.

Purpose of the Study:

  • To compare the therapeutic effects of Lycii Fructus from different geographical origins on a mouse model of retinal degenerative diseases (RDD).
  • To identify the optimal origin of Lycii Fructus for RDD treatment using multivariate statistical analysis.
  • To provide a scientific basis for selecting Lycii Fructus based on its production region for RDD prevention and treatment.

Main Methods:

  • A mouse model of RDD was induced using intraperitoneal injection of NaIO_3.
Keywords:
Lycii Fructusmultivariate statistical analysisoptic nerve protectionretinal degenerative disease

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  • Therapeutic effects were assessed through visual function tests (dark-light transition), retinal apoptosis (TUNEL assay), retinal thickness (fundus optical coherence tomography - OCT), and serum/eyeball marker analysis (antioxidant, inflammatory, angiogenic).
  • Multivariate statistical methods including hierarchical cluster analysis, principal component analysis, and partial least squares-discriminant analysis were employed to compare efficacy based on 17 pharmacodynamic indices.

    • Main Results:

    • Lycii Fructus extracts from all tested origins demonstrated protective effects against NaIO_3-induced visual damage and retinal apoptosis in mice.
    • Treatment with Lycii Fructus extracts effectively reduced oxidative stress and normalized the expression of inflammatory and angiogenic markers.
    • Multivariate analysis indicated that Lycii Fructus originating from Ningxia exhibited superior therapeutic effects on RDD compared to samples from four other regions.

    Conclusions:

    • Lycii Fructus possesses therapeutic potential for retinal degenerative diseases (RDD).
    • The origin of Lycii Fructus significantly influences its efficacy in treating RDD.
    • Ningxia Lycii Fructus is identified as a preferred source for RDD management, supported by comprehensive pharmacodynamic data.