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[A study on transference of cefminox into intrapelvic tissues]
The Japanese Journal of Antibiotics
|May 1, 1985
Summary
Cefminox (CMNX) administered intravenously showed rapid absorption and excellent distribution into female reproductive organs. These findings support its potential utility in obstetrics and gynecology treatments.
Area of Science:
- Pharmacokinetics and Drug Distribution
- Gynecological and Obstetrical Pharmacology
Context:
- Evaluating the pharmacokinetic profile of cefminox (CMNX), an antibiotic.
- Assessing drug penetration into pelvic organs is crucial for effective treatment in obstetrics and gynecology.
Purpose:
- To determine the absorption and tissue distribution of cefminox (CMNX) after intravenous administration.
- To evaluate the potential of CMNX for use in gynecological and obstetrical applications.
Summary:
- Intravenous cefminox (CMNX) at 1g demonstrated rapid absorption via both injection and infusion.
- High tissue-to-serum concentration ratios were observed in pelvic organs, including uterus (myometrium, endometrium, cervix), ovary, and oviduct.
- Specific ratios included myometrium (37.6%), endometrium (35.1%), cervix (41.4%), portio vaginalis (49.5%), ovary (54.3%), and oviduct (59.7%).
Impact:
- Confirms the significant transference of cefminox into key female reproductive tissues.
- Highlights the potential therapeutic value of cefminox in managing gynecological and obstetrical conditions.
- Provides essential pharmacokinetic data for further clinical investigation and application of CMNX.