Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ethical Dilemmas II01:30

Ethical Dilemmas II

957
Resolving an ethical dilemma in healthcare involves a systematic approach that considers every aspect of the issue, respecting both the patient's needs and values and the healthcare professional's ethical obligations. Here are potential steps to resolve an ethical dilemma:
957
Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

561
The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
561
Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

5.6K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.6K
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

74
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
74
Ethical Standards I01:25

Ethical Standards I

783
The American Nurses Association (ANA) created and implemented the first nationally accepted Code of Ethics for Nurses with Interpretive Statements. The Code of Ethics is a living document regularly updated by the ANA and establishes an ethical standard that is non-negotiable for nurses in all roles and settings.
The Code of Ethics provisions outline the nurse's duty to the patient, the healthcare team, the profession, and society. The Code's fundamental principles include advocacy,...
783
Errors occurring during blood pressure monitoring01:25

Errors occurring during blood pressure monitoring

610
Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
610

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Availability of mechanical circulatory support (MCS) and hospital survival in ST-segment elevation myocardial infarction related cardiogenic shock (STEMI-CS).

European heart journal. Acute cardiovascular care·2026
Same author

Stem-Cell-Derived Biologic Ventricular Assist Tissue in Heart Failure.

The New England journal of medicine·2026
Same author

Comparison of a long-read amplicon sequencing approach to short-read amplicons for microbiome analysis.

Microbiology spectrum·2026
Same author

Covariate Adjustment for the Win Odds: Application to Cardiovascular Outcomes Trials.

Statistics in medicine·2026
Same author

Effect of anti-fibrotic therapy on regression of myocardial fibrosis after TAVI: design and rationale of the Reduce-MFA DZHK25 trial.

ESC heart failure·2026
Same author

The microRNA inhibitor CDR132L in patients with reduced left ventricular ejection fraction after myocardial infarction: a randomized phase 2 trial.

Nature medicine·2026
Same journal

Ensuring Quality in Preclinical Research: The Importance of Being Human.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Addressing Cluster-Level Treatment Effect Heterogeneity in Sample Size Determination for Hierarchical 2 × 2 Factorial Designs.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

A Multiple Imputation Approach to Distinguish Curative From Life-Prolonging Effects in the Presence of Missing Covariates.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Tests for Categorical Data Beyond Pearson: A Distance Covariance and Energy Distance Approach.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Nonparametric Estimation of the Patient-Weighted While-Alive Estimand.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Two-Stage Multiple Test Procedures Controlling False Discovery Rate With Auxiliary Variable and Their Application to Set4 <math><semantics><mi>Δ</mi> <annotation>$\Delta$</annotation></semantics></math> Mutant Data.

Biometrical journal. Biometrische Zeitschrift·2026
See all related articles

Related Experiment Video

Updated: Jun 12, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.2K

Stakeholders' Perspectives on Current Issues in Data Monitoring Committees.

Michael J Cartwright1, Tim Friede2,3, David Lawrence4

  • 1Parexel International Ltd., Sheffield, UK.

Biometrical Journal. Biometrische Zeitschrift
|September 23, 2024
PubMed
Summary
This summary is machine-generated.

Data Monitoring Committees (DMCs) provide expert review of clinical trial data for safety and validity. This paper offers practical recommendations to improve DMC conduct, focusing on communication, open sessions, data access, and visualization.

Keywords:
benefit‐riskdata monitoring committeepatient safetystudy integrity

More Related Videos

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

11.8K
Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
11:21

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

8.2K

Related Experiment Videos

Last Updated: Jun 12, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.2K
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

11.8K
Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
11:21

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

8.2K

Area of Science:

  • Clinical Trials
  • Biostatistics
  • Pharmaceutical Industry

Background:

  • Data Monitoring Committees (DMCs) are crucial for overseeing clinical study safety and integrity.
  • Significant variability exists in current DMC practices.
  • Addressing these inconsistencies is vital for optimal study oversight.

Purpose of the Study:

  • To provide practical recommendations for enhancing Data Monitoring Committee (DMC) functionality.
  • To address variability in DMC conduct by focusing on key operational aspects.
  • To bridge the gap between current practices and optimal DMC performance.

Main Methods:

  • Recommendations derived from the 2023 Central European Network International Biometric and Statisticians in the Pharmaceutical Industry Conferences.
  • Authors' collective experience in DMC operations.
  • Focus on four critical areas: communication, open sessions, efficacy data access, and interactive data displays.

Main Results:

  • Emphasizes the importance of clear communication channels between DMCs and stakeholders.
  • Discusses the benefits and potential pitfalls of incorporating open sessions in DMC meetings.
  • Highlights the need for appropriate DMC access to efficacy data, including strategies for managing multiplicity concerns.
  • Recommends the use of interactive data displays for improved understanding of study results.

Conclusions:

  • Implementing these recommendations can enhance DMC effectiveness and study integrity.
  • Standardized practices in key areas will lead to more consistent and reliable DMC oversight.
  • Improved DMC functionality supports the safety of study participants and the validity of clinical trial outcomes.