"Recurrent Pleomorphic Xanthoastrocytoma Presenting with Diffuse Leptomeningeal Spread".

Area of Science:

• Neuro-oncology
• Radiation Oncology

Background:

• Recurrent pleomorphic xanthoastrocytoma (PXA) with leptomeningeal dissemination presents significant management challenges.
• Limited data exists on effective treatments for advanced PXA with leptomeningeal spread.

Purpose of the Study:

• To highlight the role of radiotherapy in managing recurrent pleomorphic xanthoastrocytoma (PXA) with leptomeningeal dissemination.
• To present a case demonstrating the efficacy of palliative radiotherapy for symptom control and survival extension.

Main Methods:

• A case report of a 27-year-old female with recurrent anaplastic PXA and leptomeningeal spread.
• Treatment included surgical excision, initial radiotherapy, temozolomide, and subsequent palliative spinal axis radiotherapy for leptomeningeal disease.

Main Results:

• The patient achieved initial disease control but experienced recurrence with leptomeningeal spread.
• Palliative radiotherapy to the spinal axis resulted in clinical stability.
• The treatment improved quality of life and potentially prolonged survival.

Conclusions:

• Palliative radiotherapy is a valuable option for symptom management in recurrent PXA with leptomeningeal dissemination.
• Considering radiotherapy can improve quality of life and survival outcomes in these challenging cases.