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Updated: Aug 6, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
Modified Bridge-Enhanced Anterior Cruciate Ligament Repair
David E Kantrowitz1, Christon N Darden1, Eric D Haunschild1
1Department of Orthopedic Surgery, Mount Sinai Health System, New York, New York, U.S.A.
Abstract:
Historically, the treatment of anterior cruciate ligament (ACL) injuries shifted from primary repair to reconstruction because the native, intrasynovial location of the ACL precluded the formation of a fibrin-rich clot needed for ligament healing. However, increasing attention has been paid to augmenting the biological environment surrounding the ACL to facilitate its healing after arthroscopic repair. The bridge-enhanced ACL restoration implant uses resorbable collagen mixed with autologous blood to provide a biological scaffold for tissue healing. The short-term results of this procedure are promising, showing noninferiority to traditional ACL reconstruction at 2 years postoperatively and a higher rate of return to sport at 6 months. Our technique for performing the bridge-enhanced ACL repair is efficient, is easy to learn, and achieves excellent fixation of the ACL stump augmented with an internal brace.
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